'Scared' Christina Applegate Received Important Advice From Jamie-Lynn Sigler After Her MS Diagnosis

When Christina Applegate was first diagnosed with multiple sclerosis, she was looking for someone who understood what life with the disabling disease actually looked like. That person was Jamie-Lynn Sigler.

During the Tuesday, May 12 episode of Not Skinny But Not Fat, the former Sopranos star opened up about how her friendship with Applegate began after the actress was diagnosed in 2021 while filming Dead to Me.

"Initially our conversations were like…this is what you should ask for [on set]…ask for your trailer closer…do this before you work to loosen up your legs," Sigler, 44, explained. "Like I was just trying to give her like tips and tricks of like how to work with MS basically on a film set."

But according to Sigler, those chats quickly turned into a meaningful friendship.

"She would just like call me late at night or early in the morning and just when she's scared, or she's feeling things," she shared. "And next thing you know, it's like two hours later, and we're talking about Bravo and our children and peeing our pants and all these things."

Sigler also credited Applegate, 54, with helping her become more open about her own diagnosis after years of hiding it. "She said to me one day, she's like, ‘We should do a podcast,'" Sigler recalled about the inception of their 2024 podcast, MeSsy. "‘Like I'm ready. Are you ready to just not give a sh*t and just put it all out there?'"

READ MORE: Christina Applegate Breaks Silence After Reported Hospitalization

The conversation comes shortly after reports surfaced that Applegate had recently been hospitalized in Los Angeles. According to TMZ, the actress was admitted in late March, though the exact reason for the hospitalization was not disclosed. It also remains unclear whether the reported stay was related to her MS diagnosis.

Applegate later reassured fans in an Instagram post shared April 20, writing, "Health Issues are a constant for me, but I'm a strong chick and I'm getting stronger and better everyday."

The Anchorman star recently gave Sigler her own shoutout after the release of Sigler's memoir And So It Is..., earlier this month. "Congratulations on your book release my friend! You're my absolute hero! Your support for women is unmatched. Me love you long time," Applegate wrote on her Instagram, along with a photo of the book.

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This story was originally published May 12, 2026 at 1:05 PM.