Washington Nationals (34-29) at San Francisco Giants (42-23), 10:15 p.m. (ET)

06/11/2014 7:34 AM

06/11/2014 7:37 AM

(SportsNetwork.com) - Matt Cain and Tanner Roark both responded very well to a bit of adversity last time out. The two hurlers square off on Wednesday night when Cain's San Francisco Giants resume a four-game series against Roark and the Washington Nationals.

Both Cain and Roark were last in action on Friday, with Cain coming back from his second stint on the disabled list and Roark trying to snap a personal three-start losing streak.

The right-handed Cain, returning from a hamstring strain, was in top form early on against the New York Mets, carrying a no-hitter through five innings in an eventual no-decision. He allowed two runs on three hits and a walk over seven frames as his club picked up a 4-2 win.

"You're excited to get back out there," said Cain. "You're thinking about just finding a good rhythm. For me I kind of recognize (the no-hitter), so I recognized that really early."

It marked Cain's fifth straight outing without a defeat, though he has just one win in that span. The 29-year-old is 1-3 on the year with a 3.52 earned run average.

Roark, meanwhile, was nearly lights out as well against the San Diego Padres in snapping his slide. The 27-year-old righty logged eight scoreless innings of three-hit ball, fanning a career-high 11 batters and not issuing a walk.

He allowed three runs or fewer for a sixth start in a row and is 4-4 on the year with a 2.91 ERA.

"He's been pitching like that for us all year," Nationals manager Matt Williams said. "He continues to pound the zone with all his pitches, pretty impressive."

Cain is 5-4 with a 3.12 ERA in his career against the Nationals, while Roark will face the Giants for the first time as a starter. He has faced them once in relief, picking up a victory.

The Nationals have won the first two contests of this series, claiming last night's contest by a 2-1 score.

Washington got both of its runs in the fifth inning on Denard Span's sacrifice fly and Jayson Werth's RBI single, and starter Doug Fister took care of the rest.

Fister hurled seven scoreless innings, scattering eight hits and a walk in Washington's seventh victory in eight games.

"Guys are playing together. We're rolling, we're playing together," said Fister. "We've got a lot of momentum."

Brandon Hicks' ground out in the ninth inning scored a run for the Giants, who had won five in a row coming into this series, but Rafael Soriano recorded the next two outs to record the save and secure a tough-luck loss for San Francisco starter Madison Bumgarner.

Bumgarner was shooting for his ninth win of the campaign and yielded the two runs over seven innings.

Though Washington third baseman Anthony Rendon returned from a three-game absence caused by a sore right thumb, catcher Wilson Ramos exited in the ninth inning due to right hamstring tightness. He is day-to-day.

The Giants and Nationals split six meetings a season ago.

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