OK, everybody, now's our chance.
With the New England Patriots taking a week off from their 2007 Destruction Tour to laugh at the rest of the NFL, many fantasy league leaders are suddenly vulnerable, giving the rest of us our best, and perhaps only, shot at making up serious ground.
Because of the importance of getting it right now more than ever, we'll leave the usual ranting, gardening tips, beer trivia and Jim Plunkett worship for another day and focus on getting the most out of our lineups.
Here's a position-by-position rundown of players with favorable matchups:
PLAY 'EM -- Ben Roethlisberger (vs. Browns), Tony Romo (at Giants), Matt Hasselbeck (vs. 49ers), Peyton Manning (at Chargers), Eli Manning (vs. Cowboys), Brett Favre (at Vikings), Drew Brees (vs. Rams).
Quick, name the only other QB not named Tom Brady with 20 TD passes. Romo? Close (19), but not quite. Manning? Try again. Frank Stallone? Um, no. It's Roethlisberger, who would be in the MVP discussion any other year.
If Big Ben can throw for five TD passes against the Ravens by halftime, imagine the possibilities against Cleveland's gingerbread defense.
Sunday's Giants-Cowboys tilt has shootout written all over it, which means Romo and Manning should deliver right around 3 TDs and 300 yards apiece. The red-hot Brees could throw for 600 yards against the Rams.
WORTH A GAMBLE -- J.P. Losman (at Dolphins). An injury to rookie Trent Edwards put Losman back in the Bills' starting lineup, but his ability to hook up with star receiver Lee Evans should keep him there. Losman could go off against the Dolphins and is a low-risk/high-reward option for owners, particularly those who won't have Brady to bail them out if Shaun Alexander runs for another 27 yards on 22 carries.
PLAY 'EM -- Adrian Peterson (at Packers), Joseph Addai (at Chargers), Marshawn Lynch (at Dolphins), LaDainian Tomlinson (vs. Colts), Willie Parker (at Browns).
This just in: Peterson is really, really good. Just ask the Chargers. And the Bears. And any defender who has either tried to tackle or run with Minnesota's explosive rookie.
Peterson isn't the only newcomer making himself at home in the NFL. Lynch is quietly leading Buffalo back to respectability and, like Losman, could enjoy the game of his life against Miami. Tomlinson will bounce back after a so-so performance against the Vikings, Addai should have as much fun running against the Chargers as Peterson did, and the Steelers might even let Parker score a touchdown this week.
WORTH A GAMBLE -- Justin Fargas (vs. Bears) and Priest Holmes (vs. Broncos) -- Fargas has turned the Raiders' once-crowded backfield into a committee of one by averaging 5.4 yards per carry (fourth best in the NFL) and emerging as Oakland's only reliable rusher. Meanwhile, the Chiefs' Holmes could make it feel like old times at Arrowhead Stadium filling in for the injured Larry Johnson and going up against a Denver defense that scares only Broncos fans and head coach Mike Shanahan.
PLAY 'EM -- Marques Colston (vs. Rams), Braylon Edwards (at Steelers), Terrell Owens (at Giants), Plaxico Burress (vs. Cowboys), Lee Evans (at Dolphins), Reggie Wayne (at Chargers), T.J. Houshmandzadeh (at Ravens).
The sophomore jinx doesn't apply to Colston (44 rec., 507 yards, 5 TDs), who is having another great season for the Saints. With Brees back in gunslinger mode, Colston is a good bet to catch double-digit passes against the Rams.
START AT YOUR OWN RISK -- Steve Smith (vs. Falcons). It wasn't enough to have Smith -- held under 50 yards in five of the Panthers' last six games -- be an issue in one league, so I went ahead and added him in my other league, too.
Smith is persona non catcha when David Carr is in at quarterback, but all signs point to Vinny Testaverde starting on Sunday. Testaverde probably knows all of four plays in the Panthers' playbook, but he honors Rule No. 1 -- Get the Ball to No. 89.
If Vinny starts, Smith will be fine. If Carr gets the nod, cross your fingers and do the happy dance.
PLAY 'EM -- Jason Witten (at Giants), Jeremy Shockey (at Cowboys), Heath Miller (vs. Browns), Antonio Gates (vs. Colts).
It's always a shootout when the Giants and Cowboys hook up, and Witten and Shockey always seem to be at the heart of it. Expect more of the same with both defenses determined to deny deep threats Owens and Burress (which won't happen).
Others who should come up big are Gates, a must-start every week, and Miller, who is fast becoming the Cris Carter of tight ends: All he does is catch touchdowns.
Stu Rosenberg's fantasy sports column runs Fridays. He can be reached at firstname.lastname@example.org or 578-2300.